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Quinazoline-Directed C–H Bond Functionalization Catalyzed by Ruthenium(II) Carboxylate – Construction of Polyconjugated Aryl-Heteroaryl Systems.
- Source :
-
European Journal of Organic Chemistry . 4/10/2017, Vol. 2017 Issue 14, p1855-1864. 10p. 3 Diagrams, 2 Charts. - Publication Year :
- 2017
-
Abstract
- A series of coupling products have been prepared by a ruthenium(II)-catalyzed direct ortho-C–H arylation of 2-(aryl/heteroaryl)-substituted quinazolines with (hetero)aryl bromides. Tri(hetero)aryl-substituted alkenes were also prepared by olefinic C–H activation of 2-(2-arylvinyl)quinazoline derivatives. High conversions and selectivities were achieved by choosing the appropriate ruthenium(II) carboxylate catalyst system, solvent, and reaction temperature. The possibility of a C(sp3)–H functionalization by applying an arylation/reduction reaction sequence was also demonstrated. [ABSTRACT FROM AUTHOR]
- Subjects :
- *QUINAZOLINE
*CARBOXYLATES
*CONJUGATED polymers
*ARYLATION
RUTHENIUM isotopes
Subjects
Details
- Language :
- English
- ISSN :
- 1434193X
- Volume :
- 2017
- Issue :
- 14
- Database :
- Academic Search Index
- Journal :
- European Journal of Organic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 122473661
- Full Text :
- https://doi.org/10.1002/ejoc.201700097