Back to Search
Start Over
Cost-Utility Analysis of Three Iron Chelators Used in Monotherapy for the Treatment of Chronic Iron Overload in β-Thalassaemia Major Patients: An Italian Perspective.
- Source :
-
Clinical Drug Investigation . May2017, Vol. 37 Issue 5, p453-464. 12p. - Publication Year :
- 2017
-
Abstract
- Purpose: Deferiprone (DFP), deferasirox (DFX) and deferoxamine (DFO) are used in thalassaemia major (TM) patients to treat chronic iron overload. We evaluated the cost-effectiveness of DFP, compared with DFX and DFO monotherapy, from an Italian healthcare system perspective. Methods: A Markov model was used over a time horizon of 5 years. Italian-specific cost data were combined with Italian efficacy data. Costs and quality-adjusted life years (QALYs) were calculated for each treatment, with cost-effectiveness expressed as cost per QALY. Results: In all scenarios modelled, DFP was the dominant treatment strategy. Sensitivity analyses showed that DFP dominated the other treatments with a >99% likelihood of being cost-effective against DFX and DFO at a willingness to pay threshold of €20,000 per QALY. Conclusions: DFP was the dominant and most cost-effective treatment for managing chronic iron overload in TM patients. Its use can result in substantial cost savings for the Italian healthcare system. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 11732563
- Volume :
- 37
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Clinical Drug Investigation
- Publication Type :
- Academic Journal
- Accession number :
- 122540529
- Full Text :
- https://doi.org/10.1007/s40261-017-0496-1