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Cost-Utility Analysis of Three Iron Chelators Used in Monotherapy for the Treatment of Chronic Iron Overload in β-Thalassaemia Major Patients: An Italian Perspective.

Authors :
Pepe, Alessia
Rossi, Giuseppe
Bentley, Anthony
Putti, Maria
Frizziero, Ludovica
D'Ascola, Domenico
Cuccia, Liana
Spasiano, Anna
Filosa, Aldo
Caruso, Vincenzo
Hanif, Aishah
Meloni, Antonella
Source :
Clinical Drug Investigation. May2017, Vol. 37 Issue 5, p453-464. 12p.
Publication Year :
2017

Abstract

Purpose: Deferiprone (DFP), deferasirox (DFX) and deferoxamine (DFO) are used in thalassaemia major (TM) patients to treat chronic iron overload. We evaluated the cost-effectiveness of DFP, compared with DFX and DFO monotherapy, from an Italian healthcare system perspective. Methods: A Markov model was used over a time horizon of 5 years. Italian-specific cost data were combined with Italian efficacy data. Costs and quality-adjusted life years (QALYs) were calculated for each treatment, with cost-effectiveness expressed as cost per QALY. Results: In all scenarios modelled, DFP was the dominant treatment strategy. Sensitivity analyses showed that DFP dominated the other treatments with a >99% likelihood of being cost-effective against DFX and DFO at a willingness to pay threshold of €20,000 per QALY. Conclusions: DFP was the dominant and most cost-effective treatment for managing chronic iron overload in TM patients. Its use can result in substantial cost savings for the Italian healthcare system. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
11732563
Volume :
37
Issue :
5
Database :
Academic Search Index
Journal :
Clinical Drug Investigation
Publication Type :
Academic Journal
Accession number :
122540529
Full Text :
https://doi.org/10.1007/s40261-017-0496-1