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Vitamin D receptor expression levels determine the severity and complexity of disease progression among leprosy reaction patients.

Authors :
Mandal, D.
Reja, A.H.H.
Biswas, N.
Bhattacharyya, P.
Patra, P.K.
Bhattacharya, B.
Source :
New Microbes & New Infections. Jul2015, Vol. 6, p35-39. 5p.
Publication Year :
2015

Abstract

We studied the roles of vitamin D and its receptor, VDR, in the progression of leprosy. The majority of individuals with leprosy from Kolkata, India, with a type 1 or type 2 reaction have low levels of vitamin D 3 in serum samples. Interestingly, individuals with a type 2 reaction associated with neuritis/erythema nodosum leprosum had very low VDR mRNA expression levels, ranging from 5% to 10%, compared to that of healthy control subjects; these patients also had a high bacilli index, ranging from 3+ to 5+. This is the first report to indicate that VDR expression levels may determine the complexity and severity of the progression of leprosy. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
20522975
Volume :
6
Database :
Academic Search Index
Journal :
New Microbes & New Infections
Publication Type :
Academic Journal
Accession number :
122623836
Full Text :
https://doi.org/10.1016/j.nmni.2015.04.001