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Vitamin D receptor expression levels determine the severity and complexity of disease progression among leprosy reaction patients.
- Source :
-
New Microbes & New Infections . Jul2015, Vol. 6, p35-39. 5p. - Publication Year :
- 2015
-
Abstract
- We studied the roles of vitamin D and its receptor, VDR, in the progression of leprosy. The majority of individuals with leprosy from Kolkata, India, with a type 1 or type 2 reaction have low levels of vitamin D 3 in serum samples. Interestingly, individuals with a type 2 reaction associated with neuritis/erythema nodosum leprosum had very low VDR mRNA expression levels, ranging from 5% to 10%, compared to that of healthy control subjects; these patients also had a high bacilli index, ranging from 3+ to 5+. This is the first report to indicate that VDR expression levels may determine the complexity and severity of the progression of leprosy. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 20522975
- Volume :
- 6
- Database :
- Academic Search Index
- Journal :
- New Microbes & New Infections
- Publication Type :
- Academic Journal
- Accession number :
- 122623836
- Full Text :
- https://doi.org/10.1016/j.nmni.2015.04.001