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[11C]5-hydroxy-tryptophan PET for Assessment of Islet Mass During Progression of Type 2 Diabetes.
- Source :
-
Diabetes . May2017, Vol. 66 Issue 5, p1286-1292. 7p. 1 Chart, 6 Graphs. - Publication Year :
- 2017
-
Abstract
- [11C]5-hydroxy-tryptophan ([11C]5-HTP) positron emission tomography of the pancreas has been shown to be a surrogate imaging biomarker of pancreatic islet mass. The change in islet mass in different stages of type 2 diabetes (T2D) as measured by noninvasive imaging is currently unknown. Here, we describe a cross-sectional study where subjects at different stages of T2D development with expected stratification of pancreatic islet mass were examined in relation to individuals without diabetes. The primary outcome was the [11C]5-HTP uptake and retention in pancreas, as a surrogate marker for the endogenous islet mass. We found that metabolic testing indicated a progressive loss of β-cell function, but this was not mirrored by a decrease in [11C]5-HTP tracer accumulation in the pancreas. This provides evidence of retained islet mass despite decreased β-cell function. The results herein indicate that β-cell dedifferentiation, and not necessarily endocrine cell loss, constitutes a major cause of β-cell failure in T2D. [ABSTRACT FROM AUTHOR]
- Subjects :
- *TRYPTOPHAN
*POSITRON emission tomography
*TYPE 2 diabetes
*DIABETES
*ISLANDS of Langerhans
*INSULIN therapy
*HYPOGLYCEMIC agents
*ANTHROPOMETRY
*ARGININE
*BLOOD sugar
*C-peptide
*CELL differentiation
*GLUCOSE
*MAGNETIC resonance imaging
*RADIOISOTOPES
*CROSS-sectional method
*CASE-control method
*DISEASE progression
Subjects
Details
- Language :
- English
- ISSN :
- 00121797
- Volume :
- 66
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Diabetes
- Publication Type :
- Academic Journal
- Accession number :
- 122624592
- Full Text :
- https://doi.org/10.2337/db16-1449