Synthesis of 4-Formyl-4-imidazolin-2-one Nucleosides, Isomers of Uridine and 2′-Deoxyuridine †.

The syntheses of the ribo- and deoxyribonucleoside derivatives of 4-formyl-4-imidazolin-2-one, isosteric isomers of uridine and 2'-deoxyuridine, respectively, were carried out by ring contraction of the corresponding 5-bromouracil nucleosides, followed by conversion of the carboxyl side-chain of the products to the respective carboxaldehyde derivatives. [ABSTRACT FROM AUTHOR]