丝氨酸蛋白酶抑制剂PN-1的研究进展.

Serine protease inhibitor protease nexin-1 (PN-1) is encoded by the SERPINE2 gene. It belongs to a member of serine protease inhibitor superfamily, and is a kind of glycoprotein which is secreted by a variety of cells. PN-1 is a serpin that is barely detectable in the plasma but is discovered in many organs and cell types, which plays a key role in the physiological and pathological processes, such as the blood congealing, immunoreactions, plasmin fusion, inflammation and tumor suppressor. In recent years, the research of PN-1 has been paid more attention to. This article will summarize the latest research progress of PN-1 in the circulatory system, cancer, nervous system and lung-related diseases. [ABSTRACT FROM AUTHOR]