自身免疫性肝病患者外周血Th1/Th2 细胞的表达及其与肝功能的相关性研究.

Objective: To examine the expressions of Th1 and Th2 cells and their correlation with the liver function in peripheral blood of patients with Autoimmune Liver Disease (AILD).Methods:We collected the peripheral blood from 42 cases of Autoimmune Liver Disease and 11 healthy volunteers.The proportion of Thl and Th2 cells in peripheral blood lymphocyte (PBL) subsets were assessed by Flow Cytometric analysis,and we examined liver function indicators and analyzed the correlation between Th1 and Th2 cells and liver function serum biochemical parameters.Results:The percentages of Thl and Th2 cells in AILD group were both higher than the healthy controls (HC)(P＜0.05).The percentages of Th1 and Th2 cells of patients in active phase of AILD were significantly higher than the healthy controls.In the remission stage,the percentages of Th1 cells in peripheral blood lymphocyte (PBL) subsets in AILD group decreased obviously,the percentages of Th2 cells were higher than the healthy controls.And the ratios of TH1/TH2 in AILD remission group decreased obviously than the healthy controls.The percentages of Th1 cells in AILD group were positively correlated with TBIL,DBIL and GGT level (r=0.428,0.472 and 0.51 1,P=0.010,0.004 and 0.002).The ratios of TH1/TH2 were positively correlated with TBIL and DBIL level (r=0.424 and 0.405,P=0.011 and 0.016).Conclusion:The percentages of Th1 and Th2 cells in AILD patients abnormally elevated,besides the percentages of Th1 cells and the ratios of TH1/TH2 were positively correhted with liver function parameters. [ABSTRACT FROM AUTHOR]