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HIV-1 susceptibility of transgenic rat-derived primary macrophage/T cells and a T cell line that express human receptors, CyclinT1 and CRM1 genes.
- Source :
-
Genes to Cells . May2017, Vol. 22 Issue 5, p424-435. 12p. - Publication Year :
- 2017
-
Abstract
- We developed transgenic (Tg) rats that express human CD4, CCR5, CXCR4, CyclinT1, and CRM1 genes. Tg rat macrophages were efficiently infected with HIV-1 and supported production of infectious progeny virus. By contrast, both rat primary CD4+ T cells and established T cell lines expressing human CD4, CCR5, CyclinT1, and CRM1 genes were infected inefficiently, but this was ameliorated by inhibition of cyclophilin A. The infectivity of rat T cell-derived virus was lower than that of human T cell-derived virus. [ABSTRACT FROM AUTHOR]
- Subjects :
- *HIV
*T cells
*MACROPHAGES
*CYCLOPHILINS
*TRANSGENIC organisms
Subjects
Details
- Language :
- English
- ISSN :
- 13569597
- Volume :
- 22
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Genes to Cells
- Publication Type :
- Academic Journal
- Accession number :
- 122899319
- Full Text :
- https://doi.org/10.1111/gtc.12486