Synthesis, crystallographic, spectroscopic studies and biological activity of new cobalt(II) complexes with bioactive mixed sulindac and nitrogen-donor ligands.

Four novel complexes [Co(HO)(sul)] 1, [Co(2-ampy)(sul)] 2, [Co(HO)(1,10-phen) (sul)] 3 and [Co(2,9-dimephen)(sul)] 4 (sul = sulindac, 2-ampy = 2-amino pyridine, 1,10-phen = 1,10-phenanthroline and 2,9-dimeph = 2,9-dimethyl-1,10-phenanthroline) were prepared and characterized by IR, UV-Visible spectroscopy and magnetic properties. The crystal structures of complexes 1 and 4 were determined by single-crystal X-ray diffraction. In-vitro anti-bacterial activity for the prepared complexes against Gram-positive ( Staphylococcus epidermidis, Staphylococcus aureus) and Gram-negative ( Bordetella, Escherichia coli) bacteria and Yeast species ( Saccharomyces and Candida) were performed using agar well-diffusion method. Only complex 4 showed reasonable activity against yeast. All compounds showed more anti-bacterial activity against Gram-positive bacteria than Gram-negative. [ABSTRACT FROM AUTHOR]