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Synthesis of cluster mannosides via a Ugi four-component reaction and their inhibition against the binding of yeast mannan to concanavalin A
- Source :
-
Carbohydrate Research . Mar2004, Vol. 339 Issue 4, p873. 7p. - Publication Year :
- 2004
-
Abstract
- The Ugi four-component reaction (U-4CR) was utilized to prepare divalent and trivalent cluster mannosides with different scaffolds. The glycoclusters obtained were tested for their relative inhibitory potency against the binding of yeast mannan to concanavalin A by solid-phase enzyme-linked lectin assays (ELLA) using methyl α-d-mannopyranoside as a standard. Among them, a divalent mannoside containing aromatic groups showed the strongest binding affinity to concanavalin A. [Copyright &y& Elsevier]
- Subjects :
- *LECTINS
*ENZYMES
*YEAST
*IMMUNOGLOBULINS
Subjects
Details
- Language :
- English
- ISSN :
- 00086215
- Volume :
- 339
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Carbohydrate Research
- Publication Type :
- Academic Journal
- Accession number :
- 12308565
- Full Text :
- https://doi.org/10.1016/j.carres.2003.12.005