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Positive selection of type II collagen-reactive CD80high marginal zone B cells in DBA/1 mice.
- Source :
-
Clinical Immunology . May2017, Vol. 178, p64-73. 10p. - Publication Year :
- 2017
-
Abstract
- To investigate whether dysregulated selection of autoreactive marginal zone (MZ) B cells is involved in autoimmune diseases, we examined MZ B cell profile in multiple strains of mice, and found that type II collagen (CII)-reactive autoreactive CD80 high MZ B cells spontaneously developed in the DBA/1, but not in C57BL/6 mice. CD80 high MZ B cells that were characteristically found in DBA/1 mice expressed higher levels of TACI, SLAM3, and SLAM6 than the usual CD80 low MZ B cells. Notably, the CD80 high MZ B cells were more sensitive to ibrutinib, a Bruton's tyrosine kinase inhibitor, than CD80 low MZ or follicular B cells and their transient depletion via intravenous injection of ibrutinib significantly delayed the induction of collagen-induced arthritis (CIA). In summary, we suggest that the positive selection of CII-reactive CD80 high MZ B cells is a critical homeostatic process predisposing the DBA/1 mice to the CIA induction. [ABSTRACT FROM AUTHOR]
- Subjects :
- *COLLAGEN diseases
*CD80 antigen
*B cells
*LABORATORY mice
*AUTOIMMUNE diseases
Subjects
Details
- Language :
- English
- ISSN :
- 15216616
- Volume :
- 178
- Database :
- Academic Search Index
- Journal :
- Clinical Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 123100550
- Full Text :
- https://doi.org/10.1016/j.clim.2017.01.015