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Enantioselective [3+2] cycloaddition of azomethine ylides and aldehydes via Ni/bis(oxazoline)-catalyzed ring opening of N-tosylaziridines through a chirality transfer approach.
- Source :
-
Chemical Communications . 5/21/2017, Vol. 53 Issue 41, p5661-5664. 4p. - Publication Year :
- 2017
-
Abstract
- A diastereo- and enantioselective formal [3+2] cycloaddition of N-tosylaziridines and aldehydes catalyzed by a Ni(ii)-bisoxazoline complex has been accomplished. The 1,3-oxazolidine products are obtained with high diastereoselectivity, good yields (up to 99%) and high ee values (up to 96% ee). The challenging long distant stereocenter control is achieved by a chirality transfer approach. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ENANTIOSELECTIVE catalysis
*RING formation (Chemistry)
*ALDEHYDES
Subjects
Details
- Language :
- English
- ISSN :
- 13597345
- Volume :
- 53
- Issue :
- 41
- Database :
- Academic Search Index
- Journal :
- Chemical Communications
- Publication Type :
- Academic Journal
- Accession number :
- 123121878
- Full Text :
- https://doi.org/10.1039/c7cc02906c