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The Impact of Combining a Low-Tube Voltage Acquisition with Iterative Reconstruction on Total Iodine Dose in Coronary CT Angiography.
- Source :
-
BioMed Research International . 5/23/2017, Vol. 2017, p1-10. 10p. - Publication Year :
- 2017
-
Abstract
- Objectives. To assess the impact of combining low-tube voltage acquisition with iterative reconstruction (IR) techniques on the iodine dose in coronary CTA. Methods. Three minipigs underwent CCTA to compare a standard of care protocol with two alternative study protocols combining low-tube voltage and low iodine dose with IR. Image quality was evaluated objectively by the CT value, signal-to-noise ratio (SNR), and contrast-to-noise ratio (CNR) in the main coronary arteries and aorta and subjectively by expert reading. Statistics were performed by Mann–Whitney U test and Chi-square analysis. Results. Despite reduced iodine dose, both study protocols maintained CT values, SNR, and CNR compared to the standard of care protocol. Expert readings confirmed these findings; all scans were perceived to be of at least diagnostically acceptable quality on all evaluated parameters allowing image interpretation. No statistical differences were observed (all p values > 0.11), except for streak artifacts (p=0.02) which were considered to be more severe, although acceptable, with the 80 kVp protocol. Conclusions. Reduced tube voltage in combination with IR allows a total iodine dose reduction between 37 and 50%, by using contrast media with low iodine concentrations of 200 and 160 mg I/mL, while maintaining image quality. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CORONARY arteries
*ANGIOGRAPHY
*ANIMAL experimentation
*CHI-squared test
*COMPUTED tomography
*CONFIDENCE intervals
*ELECTRICITY
*ELECTROPHYSIOLOGY
*IODINE
*MEDICAL protocols
*NOISE
*PHARMACEUTICAL arithmetic
*RESEARCH funding
*SWINE
*THREE-dimensional imaging
*DATA analysis software
*MEDICAL artifacts
*MANN Whitney U Test
*ANATOMY
Subjects
Details
- Language :
- English
- ISSN :
- 23146133
- Volume :
- 2017
- Database :
- Academic Search Index
- Journal :
- BioMed Research International
- Publication Type :
- Academic Journal
- Accession number :
- 123181193
- Full Text :
- https://doi.org/10.1155/2017/2476171