4Z- and 4E-12-deoxydihydrokromycins, two naturally occurring kromycin aglycones of pikromycin from Streptomyces sp.

Authors :: Yang, Inho
Yoon, Jisoo
Kim, Dayoung
Hahn, Dongyup
Nam, Sang-Jip
Fenical, William
Source :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry. Jun2017, Vol. 58 Issue 24, p2322-2324. 3p.
Publication Year :: 2017
Abstract: HPLC–UV guided isolation for the culture broth extract of the marine-derived bacterium Streptomyces sp. has led to the two 14-membered macrolides, 4 Z - ( 1 ) and 4 E -12-dehydroxykromycins ( 2 ). The chemical structures of compounds 1 and 2 were elucidated by spectral data, while the absolute stereochemistry of 1 and 2 were determined by application of circular dichroism (CD) and analysis of X-ray crystallographic data. [ABSTRACT FROM AUTHOR]

Subjects :: *AGLYCONES
*STREPTOMYCES
*MACROLIDE antibiotics
*STEREOCHEMISTRY
*CIRCULAR dichroism

Language :: English
ISSN :: 00404039
Volume :: 58
Issue :: 24
Database :: Academic Search Index
Journal :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry
Publication Type :: Academic Journal
Accession number :: 123195262
Full Text :: https://doi.org/10.1016/j.tetlet.2017.03.088

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