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Evaluation of 4-methylcyclohexanemethanol (MCHM) in a combined irritancy and Local Lymph Node Assay (LLNA) in mice.

Authors :
Johnson, Victor J.
Auerbach, Scott S.
Luster, Michael I.
Waidyanatha, Suramya
Masten, Scott A.
Wolfe, Mary S.
Burleson, Florence G.
Burleson, Gary R.
Germolec, Dori R.
Source :
Food & Chemical Toxicology. Jul2017, Vol. 105, p99-105. 7p.
Publication Year :
2017

Abstract

4-Methylcyclohexanemethanol (MCHM) is a flotation reagent used in fine coal beneficiation. On January 9, 2014, crude MCHM, a mixture containing predominantly MCHM, was inadvertently released into the Elk River, a municipal water source that serves about 300,000 people in the Charleston, WV area, resulting in temporary contamination of 15 percent of the state's tap water and causing significant dermal exposure. The current studies were undertaken to determine whether crude MCHM or MCHM has the potential to produce dermal irritancy and/or sensitization. BALB/c female mice were treated daily for 3 consecutive days by direct epicutaneous application of 25 μL of various concentrations of crude MCHM or MCHM to the dorsum of each ear. A mouse ear-swelling test was used to determine irritancy potential and was undertaken in combination with the standardized Local Lymph Node Assay (LLNA) to determine skin sensitizing potential. MCHM was found to produce skin irritation at concentrations above 20% and did not produce sensitization. Crude MCHM also produced irritation, although weaker, and in addition was found to be a weak to moderate skin sensitizer. The results are discussed in terms of potential human health hazard. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
02786915
Volume :
105
Database :
Academic Search Index
Journal :
Food & Chemical Toxicology
Publication Type :
Academic Journal
Accession number :
123259246
Full Text :
https://doi.org/10.1016/j.fct.2017.03.034