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Observed survival benefit of mild therapeutic hypothermia reanalysing the Circulation Improving Resuscitation Care trial.
- Source :
-
European Journal of Clinical Investigation . Jun2017, Vol. 47 Issue 6, p439-446. 8p. - Publication Year :
- 2017
-
Abstract
- Background Mild therapeutic hypothermia is argued being beneficial for outcome after cardiac arrest. Materials and methods Retrospective analysis of Circulation Improving Resuscitation Care ( CIRC) trial data to assess if therapeutic cooling to 33 ± 1 °C core temperature had an association with survival. Of 4231 adult, out-of-hospital cardiac arrests of presumed cardiac origin initially enrolled, eligibility criteria for therapeutic hypothermia were met by 1812. Logistic regression was undertaken in a stepwise fashion to account for the impact on outcome of each significant difference and for the variable of interest between the groups. Results Out-of- and in-hospital cooled were 263 (15%), only after admission cooled were 230 (13%) and not cooled were 357 (20%) patients. The group cooled out of- and in hospital had 98 (37%) survivors as compared to the groups cooled in hospital only [80 (35%)] and of those not cooled [68 (19%)]. After adjusting for known covariates (sex, age, witnessed cardiac arrest, no- and low-flow time, shockable initial rhythm, random allocation, bystander cardiopulmonary resuscitation and percutaneous coronary intervention), the odds ratio for survival comparing no cooling to out-of- plus in-hospital cooling was 0·53 [95% confidence interval ( CI): 0·46-0·61, P < 0·001], and comparing to in-hospital cooling only was 0·67 (95% CI: 0·50-0·89, P = 0·006). Conclusion Mild therapeutic hypothermia initiated out of hospital and/or in hospital was associated with improved survival within this secondary analysis of the CIRC cohort compared to no therapeutic hypothermia. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00142972
- Volume :
- 47
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- European Journal of Clinical Investigation
- Publication Type :
- Academic Journal
- Accession number :
- 123283447
- Full Text :
- https://doi.org/10.1111/eci.12759