Back to Search
Start Over
Enantioselective alkynylation of N-sulfonyl α-ketiminoesters via a Friedel–Crafts alkylation strategy.
- Source :
-
Chemical Communications . 5/28/2017, Vol. 53 Issue 43, p5890-5893. 4p. - Publication Year :
- 2017
-
Abstract
- Enantioselective alkynylation of cyclic N-sulfonyl α-ketiminoesters with terminal alkynes was developed by using an Ni(ClO4)2/(R)-DTBM-Segphos complex as a catalyst. A range of propargylic amides bearing quaternary stereocenters were afforded in excellent enantioselectivities (up to 97% ee). Theoretical studies revealed that this reaction proceeded via a Friedel–Crafts-type reaction pathway. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ENANTIOSELECTIVE catalysis
*HETEROGENEOUS catalysis
*ESTERS
*ALKYNES
*HYDROCARBONS
Subjects
Details
- Language :
- English
- ISSN :
- 13597345
- Volume :
- 53
- Issue :
- 43
- Database :
- Academic Search Index
- Journal :
- Chemical Communications
- Publication Type :
- Academic Journal
- Accession number :
- 123319807
- Full Text :
- https://doi.org/10.1039/c7cc01015j