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Hydroxytrifluoromethylation of Alkenes Using Fluoroform-Derived CuCF3.
- Source :
-
Organic Letters . May2017, Vol. 19 Issue 9, p2446-2449. 4p. - Publication Year :
- 2017
-
Abstract
- Hydroxytrifluoromethylation of alkenes using the fluoroform (CF3H)-derived [CuCF3] reagent is described. In the presence of additive B2Pin2 and air, this reagent effectively facilitates the addition of hydroxy and trifluoromethyl groups across an alkene double bond, a formal hydroxytrifluoromethylation process. Various β-trifluoromethyl alcohols can be synthesized from simple alkenes where the ultimate CF3 source is the industrial byproduct fluoroform. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15237060
- Volume :
- 19
- Issue :
- 9
- Database :
- Academic Search Index
- Journal :
- Organic Letters
- Publication Type :
- Academic Journal
- Accession number :
- 123353952
- Full Text :
- https://doi.org/10.1021/acs.orglett.7b01085