1,4-Phenylenediisothiocyanate in The Synthesis of Bis-(thiourea, Benzothiazole, Quinazoline, 1,3-Benzoxazine and Imidazolidineiminothiones) Derivatives.

Interaction of 1,4-phenylenediisothiocyanate 1 with aromatic amines and o-phenylenediamine furnished the novel bisthiourea derivatives 2a-c and 7 . Hydrazines or o-aminothiophenol reacted with 1 to produce bis-(thiosemicarbazide 4a,b or benzothiazole 9 ) derivatives. Bisquinazolines 12a,b and bisthienopyrimidines 13a,b were synthesized through interaction of 1 with anthranilic acids 10a,b and aminothiophenes 11a,b . Interaction of 1 with two moles of either salicylic acid or N-(4-substituted-phenyl)cyanothioformamide yielded the corresponding bis(1,3-benzoxazine 14 or imidazolidineiminothiones 16 ) derivatives. [ABSTRACT FROM AUTHOR]