Back to Search
Start Over
TGF-β1 improving abnormal pregnancy outcomes induced by Toxoplasma gondii infection: Regulating NKG2D/DAP10 and killer subset of decidual NK cells.
- Source :
-
Cellular Immunology . Jul2017, Vol. 317, p9-17. 9p. - Publication Year :
- 2017
-
Abstract
- Our current aim was to investigate whether injection of TGF-β1 played an important role in improving abnormal pregnancy outcomes with T. gondii infection and how the TGF-β1 regulated. Results showed that TGF-β1 exhibited improved pregnancy outcomes induced by T. gondii infection. dNK cytotoxicity was increased with T. gondii infection while decreased with TGF-β1 treatment. dNK cytotoxicity related NKG2D/DAP10 expression, perforin, granzyme, IFN-γ and killer subsets were all increased with T. gondii infection while decreased after TGF-β1 treatment. In addition, anti-TGF-β1 antibodies could aggregate the cytotoxicity of dNK cells and the levels of molecules above. These results indicated that TGF-β1 treatment could improve the abnormal pregnancy outcomes with T. gondii infection by decreasing the cytotoxicity of dNK cells mediated by NKG2D/DAP10 pathway and killer subset. These results suggested that TGF-β1 might be a potential immunoprotective method for the treatment of abnormal pregnancy outcomes following T. gondii infection. [ABSTRACT FROM AUTHOR]
- Subjects :
- *TOXOPLASMA gondii
*KILLER cells
*PERFORINS
*CELL-mediated cytotoxicity
*GRANZYMES
Subjects
Details
- Language :
- English
- ISSN :
- 00088749
- Volume :
- 317
- Database :
- Academic Search Index
- Journal :
- Cellular Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 123467323
- Full Text :
- https://doi.org/10.1016/j.cellimm.2017.04.004