ASPECTS OF MOLECULAR EVOLUTION.

This article is a critique of the meaning and importance of some of the recently published work in the field whose development as a special area began with papers by Zuckerkandl & Pauling and Pauling & Zuckerkandl entitled Chemical Paleogenetics, Molecular Restoration Studies of Extinct Forms of Life and the paper by Margoliash on the evolution of cytochrome c. The primary emphasis is on conclusions and inferences derivable from amino acid sequences, followed bya section on nucleotide sequences. These are preceded by a brief indication of some of the literature that antedates the origin of the genetic code as it now stands. This will not treat immunoglobulin evolution, reviewed by Gally & Edelma and Smith, Hood & Fitch or related material on the evolution of enzymes and proteins reviewed by Smith and Arnheim. The functional interpretation of these changes has made significant progress [Dickerson and Takano et al]. For the evolution of metabolic pathways, see brew, Vogel, and Lejohn. [ABSTRACT FROM AUTHOR]