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Hematopoietic stem progenitor cells prevent chronic stress-induced lymphocyte apoptosis.
- Source :
-
Journal of Neuroimmunology . Aug2017, Vol. 309, p72-76. 5p. - Publication Year :
- 2017
-
Abstract
- Physical or psychological chronic stress can suppress the immune system. However, the mechanisms remain to be elucidated. We investigated the effect of hematopoietic stem-progenitor cells (HSPCs) on chronic stress-induced the alterations of immune responses. We demonstrate that HSPCs prevents stress-induced lymphocyte apoptosis. Moreover, we also demonstrate that the protective effect of HSPCs on stress-induced lymphocyte reduction exerts by steroid hormones. Furthermore, we reveal that chronic stress-induced T cell-mediated immune responses contributes to the protective effect of HSPCs. These results indicate that HPSCs might offer a novel therapeutic strategy against the deleterious effects of chronic stress on the immune system. [ABSTRACT FROM AUTHOR]
- Subjects :
- *PROGENITOR cells
*LYMPHOCYTES
*DELAYED hypersensitivity
*DEXAMETHASONE
*APOPTOSIS
Subjects
Details
- Language :
- English
- ISSN :
- 01655728
- Volume :
- 309
- Database :
- Academic Search Index
- Journal :
- Journal of Neuroimmunology
- Publication Type :
- Academic Journal
- Accession number :
- 123501128
- Full Text :
- https://doi.org/10.1016/j.jneuroim.2017.05.014