Back to Search
Start Over
A surface molecularly imprinted polymer as chiral stationary phase for chiral separation of 1,1′-binaphthalene-2-naphthol racemates.
- Source :
-
Chirality . Jul2017, Vol. 29 Issue 7, p340-347. 8p. - Publication Year :
- 2017
-
Abstract
- Acrylamide (AM) was copolymerized with ethylene glycol dimethacrylate (EGDMA) in the presence of ( R)-1,1′-binaphthalene-2-naphthol (BINOL) as the template molecules on the surface of silica gel by a free radical polymerization to produce a chiral stationary phase based on the surface molecularly imprinted polymer (SMIP-CSP). The SMIP-CSP showed a much better separation factor ( α = 4.28) than the CSP based on the molecularly imprinted polymer (MIP-CSP) without coating on the silica gel ( α = 1.96) during the chiral separation of BINOL enantiomers by high-performance liquid chromatography. The influence of the pretreatment temperature and the content of the template molecule (( R)-BINOL) of the SMIP-CSP, and the mobile phase composition on the separation of the racemic BINOL were systematically investigated. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 08990042
- Volume :
- 29
- Issue :
- 7
- Database :
- Academic Search Index
- Journal :
- Chirality
- Publication Type :
- Academic Journal
- Accession number :
- 123567079
- Full Text :
- https://doi.org/10.1002/chir.22710