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Clinical implications of plasma Nogo-A levels in patients with coronary heart disease.
- Source :
-
Archives of Medical Science . 2017, Vol. 13 Issue 4, p771-777. 7p. 2 Charts, 3 Graphs. - Publication Year :
- 2017
-
Abstract
- <bold>Introduction: </bold>Nogo-A is an important neurite growth-regulatory protein in the adult and developing nervous system. Recently, increasing evidence has shown that Nogo-A plays important roles in cardiac development and may act as a potential indicator for heart failure. In addition, increased oxidative stress has been found in individuals with cardiovascular diseases. However, not much is known regarding the expression levels of Nogo-A and reactive oxygen species (ROS) in patients with coronary heart disease (CHD). Therefore, we sought to investigate the relationship between Nogo-A, ROS levels and CHD.<bold>Material and Methods: </bold>The plasma Nogo-A and ROS concentrations of 122 acute coronary syndrome (ACS), 101 unstable angina pectoris (UAP), and 21 acute myocardial infarction (AMI) patients and 56 healthy controls were measured by enzyme-linked immunosorbent assay (ELISA). We further generated a receiver operating characteristic (ROC) curve to assess the diagnostic accuracy of Nogo-A and ROS in CHD.<bold>Results: </bold>The Nogo-A and ROS levels were significantly higher in patients with CHD than those in healthy controls. In addition, multivariate logistic regression analysis revealed that the level of Nogo-A (odds ratio (OR) = 1.624, 95% confidence interval: 1.125-2.293, p = 0.009) is a risk factor for prediction of CHD. Nogo-A has diagnostic value, with an optimal threshold of 5.466 ng/ml for maximized diagnostic performance (59% sensitivity and 78.6% specificity, area under curve, p < 0.05). However, ROS concentration is not a risk factor for prediction of CHD (OR = 0.999, 95% confidence interval: 0.997-1.001, p = 0.320).<bold>Conclusions: </bold>Increased plasma Nogo-A level may be associated with CHD. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 17341922
- Volume :
- 13
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Archives of Medical Science
- Publication Type :
- Academic Journal
- Accession number :
- 123591883
- Full Text :
- https://doi.org/10.5114/aoms.2016.58713