A segmented flow platform for on-demand medicinal chemistry and compound synthesis in oscillating droplets.

Authors :: Hwang, Ye-Jin
Coley, Connor W.
Abolhasani, Milad
Marzinzik, Andreas L.
Koch, Guido
Spanka, Carsten
Lehmann, Hansjoerg
Jensen, Klavs F.
Source :: Chemical Communications. 6/21/2017, Vol. 53 Issue 49, p6649-6652. 4p.
Publication Year :: 2017
Abstract: We report an automated flow chemistry platform that can efficiently perform a wide range of chemistries, including single/multi-phase and single/multi-step, with a reaction volume of just 14 μL. The breadth of compatible chemistries is successfully demonstrated and the desired products are characterized, isolated, and collected online by preparative HPLC/MS/ELSD. [ABSTRACT FROM AUTHOR]

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