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Relationships Between Quantitative Pulse-Echo Ultrasound Parameters from the Superficial Zone of the Human Articular Cartilage and Changes in Surface Roughness, Collagen Content or Collagen Orientation Caused by Early Degeneration.
- Source :
-
Ultrasound in Medicine & Biology . Aug2017, Vol. 43 Issue 8, p1703-1715. 13p. - Publication Year :
- 2017
-
Abstract
- We aimed to quantitatively investigate the relationship between amplitude-based pulse-echo ultrasound parameters and early degeneration of the knee articular cartilage. Twenty samples from six human femoral condyles judged as grade 0 or 1 according to International Cartilage Repair Society grading were assessed using a 15-MHz pulsed-ultrasound 3-D scanning system ex vivo. Surface roughness (Rq), average collagen content (A1) and collagen orientation (A12) in the superficial zone of the cartilage were measured via laser microscopy and Fourier transform infrared imaging spectroscopy. Multiple regression analysis with a linear mixed-effects model (LMM) revealed that a time-domain reflection coefficient at the cartilage surface (Rc) had a significant coefficient of determination with Rq and A12 (RLMMm2=0.79); however, Rc did not correlate with A1. Concerning the collagen characteristic in the superficial zone, Rc was found to be a sensitive indicator reflecting collagen disorganization, not collagen content, for the early degeneration samples. [ABSTRACT FROM AUTHOR]
- Subjects :
- *KNEE abnormalities
*ULTRASONIC imaging
*ARTICULAR cartilage
*SURFACE roughness
*COLLAGEN
*FOURIER transform infrared spectroscopy
*COMPARATIVE studies
*INFRARED spectroscopy
*KNEE
*KNEE diseases
*RESEARCH methodology
*MEDICAL cooperation
*MICROSCOPY
*OSTEOARTHRITIS
*RESEARCH
*THREE-dimensional imaging
*EVALUATION research
Subjects
Details
- Language :
- English
- ISSN :
- 03015629
- Volume :
- 43
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- Ultrasound in Medicine & Biology
- Publication Type :
- Academic Journal
- Accession number :
- 123658983
- Full Text :
- https://doi.org/10.1016/j.ultrasmedbio.2017.03.015