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Usefulness of human papillomavirus detection in oral rinse as a biomarker of oropharyngeal cancer.
- Source :
-
Acta Oto-Laryngologica . Jul2017, Vol. 137 Issue 7, p773-777. 6p. - Publication Year :
- 2017
-
Abstract
- Conclusion: The detection of human papillomavirus (HPV)-DNA in oral rinse with auto-nested GP5+/ GP6 + PCR is useful as a biomarker of oropharyngeal cancer. Background: This study aimed to determine the usefulness of oral rinse to detect HPV-DNA as a biomarker of HPV-positive oropharyngeal cancer (OPC). Patients and methods: One hundred and ten patients with various head and neck diseases, including 19 patients with OPC, were enrolled. Oral rinse and tonsillar swab were collected, and auto-nested GP5+/GP6 + PCR for HPV-DNA was performed. For oropharyngeal cancer, p16 immunostaining was also conducted. Results: The rate of HPV-DNA detection in both oral rinse and tonsillar swab was significantly higher in OPC compared with non-OPC upper respiratory tract cancer and non-cancer diseases. HPV-DNA was detected in oral rinse in nine out of 12 p16-positive OPC cases, while none of the p16-negative OPC cases demonstrated detectable HPV-DNA. All p16-positive cases were also positive for HPV-DNA in tumor tissue. Based on p16 immunostaining, the sensitivity and specificity of HPV-DNA detection in oral rinse were 75% and 100%, respectively. Among eight of nine evaluable OPC cases positive for HPV-DNA in oral rinse at diagnosis, HPV-DNA was undetectable in oral rinse in seven cases after treatment. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00016489
- Volume :
- 137
- Issue :
- 7
- Database :
- Academic Search Index
- Journal :
- Acta Oto-Laryngologica
- Publication Type :
- Academic Journal
- Accession number :
- 123742469
- Full Text :
- https://doi.org/10.1080/00016489.2016.1274426