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Heart rate variability in human immunodeficiency virus-positive individuals
- Source :
-
International Journal of Cardiology . Mar2004, Vol. 94 Issue 1, p1. 6p. - Publication Year :
- 2004
-
Abstract
- Background: Heart rate variability (HRV) is a marker of cardiac autonomic tone. Depressed HRV has been reported in patients with AIDS. We conducted this study to find out if HRV is depressed in human immunodeficiency virus (HIV)-positive individuals without AIDS. Methods: We studied prospectively HRV by spectral analysis of short-term electrocardiography (ECG) monitoring in 21 HIV-positives (33±11 years) and in 18 healthy volunteers (31±9 years). None of the HIV-positives had any clinical evidence of autonomic or cardiac dysfunction. Echocardiography was also performed in HIV-seropositives to rule out left ventricular (LV) systolic dysfunction. All these individuals did not have any evidence of AIDS. Results: Mean CD4+ lymphocyte count was 426±166/mm3. The ejection fraction (EF%) of HIV patients was 62.4±6.4.The total power of HRV was reduced significantly in HIV-positive individuals (p<0.00001). All the components of HRV were reduced. Conclusions: HRV is reduced in HIV-seropositive individuals in early stages of infection as well without any clinical evidence of autonomic dysfunction. This may serve as an early marker of future global sympatho-vagal imbalance. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 01675273
- Volume :
- 94
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- International Journal of Cardiology
- Publication Type :
- Academic Journal
- Accession number :
- 12381036
- Full Text :
- https://doi.org/10.1016/j.ijcard.2003.02.002