CuI-catalyzed Sonogashira reaction for the efficient synthesis of 1H-imidazo[2,1-a]isoquinoline derivatives.

The Sonogashira reaction first, and then intra-molecular hydroamination of alkyne catalyzed by CuI/ o -phen was proved to be an efficient method for the synthesis of imidazo[2,1- a ]isoquinoline, phenanthro[9′,10′:4,5]imidazo[2,1- a ]isoquinoline and acenaphtho[1′,2′:4,5]imidazo [2,1- a ]isoquinoline derivatives in the presence of Cs 2 CO 3 . [ABSTRACT FROM AUTHOR]