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A meta-analytical comparison of atenolol with angiotensin-converting enzyme inhibitors on arterial stiffness, peripheral blood pressure and heart rate in hypertensive patients.
- Source :
-
Clinical & Experimental Hypertension . 2017, Vol. 39 Issue 5, p421-426. 6p. - Publication Year :
- 2017
-
Abstract
- Objectives: This meta-analysis of randomized parallel controlled trials was designed to compare the efficacy of atenolol with angiotensin-converting enzyme inhibitors (ACEIs) in changing pulse wave velocity (PWV), peripheral blood pressure and heart rate (HR) among patients with essential hypertension.Methods: This study was conducted according to the PRISMA guideline. Data collection was independently completed by two investigators. Statistical analyses were completed by Stata software (v12.0).Results: Eight clinical trials were meta-analyzed in this study. Overall changes in PWV (weighted mean difference or WMD = 0.068, 95% confidence interval or CI: −0.487 to –0.623, P = 0.811) and peripheral systolic blood pressure (PSBP) (WMD = −1.281 mmHg, 95% CI: −6.936 to 4.375, P = 0.657) did not differ significantly between atenolol and ACEIs treatment. Relative to ACEIs, atenolol had a more favorable impact on peripheral diastolic blood pressure (PDBP) (WMD = −1.912 mmHg, 95% CI: −3.732 to −0.091, P = 0.040) and HR (WMD = −9.23 bpm, 95% CI: −12.53 to −5.93, P < 0.001). In stratified analyses, particularly by follow-up period, atenolol was observed to be superior over ACEIs within early 3-month treatment in PSBP (WMD = −4.097 mmHg, 95% CI: −6.589 to −1.605, P = 0.001), PDBP (WMD = −6.802 mmHg, 95% CI: −8.517 to −5.087, P < 0.001) and HR (WMD = −14.242 bpm, 95% CI: −16.427 to −12.058, P = 0.028), without heterogeneity (I2= 0.0%). There were low probabilities of publication bias for all comparisons.Conclusions: Our findings demonstrate that atenolol and ACEIs were equally effective in reducing PWV and PSBP, while atenolol was superior over ACEIs in improving PDBP and HR, especially within short-term treatment. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ATENOLOL
*ANGIOTENSINS
*ARTERIAL diseases
*BLOOD pressure
*HEART beat
Subjects
Details
- Language :
- English
- ISSN :
- 10641963
- Volume :
- 39
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Clinical & Experimental Hypertension
- Publication Type :
- Academic Journal
- Accession number :
- 124023693
- Full Text :
- https://doi.org/10.1080/10641963.2016.1267188