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Chiral N,N′-dioxide/Co(ii)-promoted asymmetric 1,3-dipolar cycloaddition of nitrones with methyleneindolinones.
- Source :
-
Chemical Communications . 7/18/2017, Vol. 53 Issue 56, p7925-7928. 4p. - Publication Year :
- 2017
-
Abstract
- A chiral N,N′-dioxide/Co(BF4)2·6H2O complex catalytic system has been developed to efficiently catalyze the asymmetric 1,3-dipolar cycloaddition of nitrones with methyleneindolinones. The corresponding chiral multisubstituted spiroisoxazolidines with three contiguous quaternary–tertiary stereocenters were obtained in moderate to high yields with excellent dr and ee values (up to 97% yield, >19 : 1 dr and 98% ee). [ABSTRACT FROM AUTHOR]
- Subjects :
- *RING formation (Chemistry)
*NITRONES
*INDOLINONE
Subjects
Details
- Language :
- English
- ISSN :
- 13597345
- Volume :
- 53
- Issue :
- 56
- Database :
- Academic Search Index
- Journal :
- Chemical Communications
- Publication Type :
- Academic Journal
- Accession number :
- 124057213
- Full Text :
- https://doi.org/10.1039/c7cc03575f