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Prognostic Value of PD-L1 in Breast Cancer: A Meta-Analysis.
- Source :
-
Breast Journal . Jul/Aug2017, Vol. 23 Issue 4, p436-443. 8p. - Publication Year :
- 2017
-
Abstract
- Programmed cell death 1 ligand 1 ( PD-L1) is a promising therapeutic target for cancer immunotherapy. However, the correlation between PD-L1 and breast cancer survival remains unclear. Here, we present the first meta-analysis to investigate the prognostic value of PD-L1 in breast cancer. We searched Pubmed, Embase, and Cochrane Central Register of Controlled Trials databases for relevant studies evaluating PD-L1 expression and breast cancer survival. Fixed- and random-effect meta-analyses were conducted based on heterogeneity of included studies. Publication bias was evaluated by funnel plot and Begg's test. Overall, nine relevant studies with 8583 patients were included. PD-L1 overexpression was found in 25.8% of breast cancer patients. PD-L1 (+) associated with several high-risk prognostic indicators, such as ductal cancer (p = 0.037), high tumor grade (p = 0.000), ER negativity (p = 0.000), PR negativity (p = 0.000), HER2 positivity (p = 0.001) and aggressive molecular subtypes ( HER2-rich and Basal-like p = 0.000). PD-L1 overexpression had no significant impact on metastasis-free survival ( HR 0.924, 95% CI = 0.747-1.141, p = 0.462), disease-free survival ( HR 1.122, 95% CI = 0.878-1.434, p = 0.357) and overall specific survival ( HR 0.837, 95% CI = 0.640-1.093, p = 0.191), but significantly correlated with shortened overall survival ( HR 1.573, 95% CI = 1.010-2.451, p = 0.045). PD-L1 overexpression in breast cancer associates with multiple clinicopathological parameters that indicated poor outcome, and may increase the risk for mortality. Further standardization of PD-L1 assessment assay and well-controlled clinical trials are warranted to clarify its prognostic and therapeutic value. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 1075122X
- Volume :
- 23
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Breast Journal
- Publication Type :
- Academic Journal
- Accession number :
- 124061376
- Full Text :
- https://doi.org/10.1111/tbj.12753