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Intake of 7,8-dihydroxyflavone from pregnancy to weaning prevents cognitive deficits in adult offspring after maternal immune activation.
- Source :
-
European Archives of Psychiatry & Clinical Neuroscience . Aug2017, Vol. 267 Issue 5, p479-483. 5p. 2 Graphs. - Publication Year :
- 2017
-
Abstract
- Brain-derived neurotrophic factor (BDNF) and its high-affinity receptor, tropomyosin receptor kinase B (TrkB) signaling plays a key role in the brain neurodevelopment. The exposure of pregnant mice to polyinosinic-polycytidylic acid [poly(I:C)] causes cognitive deficits in adult offspring. Supplementation with a TrkB agonist, 7,8-dihydroxyflavone, in poly(I:C)-treated pregnant mice from pregnancy to weaning could prevent the onset of cognitive deficits and reduced BDNF-TrkB signaling in the prefrontal cortex of their adult offspring. These findings suggest that supplementation with a TrkB agonist in pregnant women with an ultra-high risk of psychosis may reduce the development of psychosis in their offspring. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09401334
- Volume :
- 267
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- European Archives of Psychiatry & Clinical Neuroscience
- Publication Type :
- Academic Journal
- Accession number :
- 124090341
- Full Text :
- https://doi.org/10.1007/s00406-017-0802-1