Garlic-inspired trisulfide linkers for thiol-stimulated H2S release.

Authors :: Ercole, Francesca
Whittaker, Michael R.
Halls, Michelle L.
Boyd, Ben J.
Davis, Thomas P.
Quinn, John F.
Source :: Chemical Communications. 7/21/2017, Vol. 53 Issue 57, p8030-8033. 4p.
Publication Year :: 2017
Abstract: Garlic-derived polysulfides (e.g., diallyl trisulfide, DATS) act as potent donors of the cell-signalling mediator H2S when exposed to endogenous thiols. Inspired by this chemistry, we incorporated a trisulfide linkage into a conjugate comprising an mPEG tail and a cholesteryl head via thiol-mediated fragmentation chemistry. The synthesized conjugate releases H2S upon exposure to thiol even at intracellular levels. [ABSTRACT FROM AUTHOR]