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Synthesis and biological evaluation of 1,2,4,5-tetrasubstituted imidazoles.
- Source :
-
Research on Chemical Intermediates . Aug2017, Vol. 43 Issue 8, p4413-4421. 9p. 3 Diagrams, 5 Charts. - Publication Year :
- 2017
-
Abstract
- Tetrasubstituted imidazoles were synthesized in high yields via the four-component reaction of aromatic aldehydes, amines, substituted benzils and ammonium acetate catalyzed by a porous CeO nanorod. Their anti-cancer activities on the Huh-7 hepatocellular carcinoma cell and antibacterial activities on four bacterial species (wild-type Escherichia coli, wild-type Staphylococcus aureus, Pseudomonas aeruginosa PAM1032 and Escherichia coli-NMD-1) in vitro were evaluated. One compound ( 5p) was screened out because of its high inhibition rate on all four bacterials at 100 μg/mL. Three products ( 5p, 5t and 5y) showed a high inhibition rate on the Huh-7 hepatocellular carcinoma cell at 10 μg/mL. The results indicated their potential in new drug development. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09226168
- Volume :
- 43
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- Research on Chemical Intermediates
- Publication Type :
- Academic Journal
- Accession number :
- 124132092
- Full Text :
- https://doi.org/10.1007/s11164-017-2886-7