Efectul exercitat de virusul hepatitei C asupra statusului prooxidant al gama-glutamil transpeptidazei la pacienţii cu lichen plan.

Lichen planus (LP) is an autoimmune, inflammatory skin disorder commonly associated with hepatitis C virus (HCV) infection. Gamma-glutamyl transpeptidase (GGT) plays an important role in modulating the skin response to various internal or external injuries. In order to evaluate the effects of HCV on GGT pro-oxidative activities, we performed a comparative study between LP patients without viral infections and patients with asymptomatic HCV infection (HCV carriers). Our conclusion is that asymptomatic HCV infection induces a functional GGT deficiency, resulting in the alteration of the enzyme’s ability to reduce the toxic effects of free radicals, neutralize unstable oxygen species and prevent the oxidation of certain molecules in the infected tissue. [ABSTRACT FROM AUTHOR]