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Asymmetric Yttrium-Catalyzed C(sp3)−H Addition of 2-Methyl Azaarenes to Cyclopropenes.
- Source :
-
Angewandte Chemie . 7/24/2017, Vol. 129 Issue 31, p9335-9338. 4p. - Publication Year :
- 2017
-
Abstract
- An enantioselective C−H addition to a C=C bond represents the most atom-efficient route for the construction of chiral carbon-carbon skeletons, a central research topic in organic synthesis. We herein report the enantioselective yttrium-catalyzed C(sp3)−H bond addition of 2-methyl azaarenes, such as 2-methyl pyridines, to various substituted cyclopropenes and norbornenes. This process efficiently afforded a new family of chiral pyridylmethyl-functionalized cyclopropane and norbornane derivatives in high yields and high enantioselectivities (up to 97 % ee). [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00448249
- Volume :
- 129
- Issue :
- 31
- Database :
- Academic Search Index
- Journal :
- Angewandte Chemie
- Publication Type :
- Academic Journal
- Accession number :
- 124204110
- Full Text :
- https://doi.org/10.1002/ange.201705431