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Identification of STS-1 as a novel ShcA-binding protein.

Authors :
van der Meulen, Talitha
Swarts, Spencer
van der Geer, Peter
Fischer, Wolfgang
Source :
Biochemical & Biophysical Research Communications. Sep2017, Vol. 490 Issue 4, p1334-1339. 6p.
Publication Year :
2017

Abstract

ShcA is a cytoplasmic signaling protein that supports signal transduction by receptor protein-tyrosine kinases by providing auxiliary tyrosine phosphorylation sites that engage additional signaling proteins. The principal binding partner for tyrosine phosphorylation sites on ShcA is Grb2. In the current study, we have used phosphotyrosine-containing peptides to isolate and identify STS-1 as a novel ShcA-binding protein. Our results further show that the interaction between STS-1 and ShcA is regulated in response to EGF receptor activation. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
0006291X
Volume :
490
Issue :
4
Database :
Academic Search Index
Journal :
Biochemical & Biophysical Research Communications
Publication Type :
Academic Journal
Accession number :
124288621
Full Text :
https://doi.org/10.1016/j.bbrc.2017.07.024