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CuX-Activated N-Halosuccinimide: Synthesis of 3-Haloquinolines via Electrophilic Cyclization of Alkynyl Imines.
- Source :
-
Journal of Organic Chemistry . 5/5/2017, Vol. 82 Issue 9, p4625-4630. 6p. - Publication Year :
- 2017
-
Abstract
- We report an electrophilic cyclization of alkynyl imines to afford polysubstituted 3-haloquinolines using CuX-activated N-halosuccinimdes (NXS) as electrophiles. Control experiments demonstrated that the NXS/CuX system might be more active than single NXS and could be applied in the electrophilic cyclization of electron-deficient substrates. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00223263
- Volume :
- 82
- Issue :
- 9
- Database :
- Academic Search Index
- Journal :
- Journal of Organic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 124295677
- Full Text :
- https://doi.org/10.1021/acs.joc.7b00131