Back to Search
Start Over
Effects of SGLT-2 inhibitors on diabetic ketoacidosis: A meta-analysis of randomised controlled trials.
- Source :
-
Diabetes Research & Clinical Practice . Aug2017, Vol. 130, p53-60. 8p. - Publication Year :
- 2017
-
Abstract
- <bold>Aims: </bold>Diabetic ketoacidosis (DKA) associated with SGLT-2 inhibitors (SGLT-2i) is a possible adverse event. In fact, SGLT-2i are capable of stimulating the release of glucagon and ketone re-absorption in the renal tubuli, thus increasing the concentration of ketone bodies.<bold>Methods: </bold>A Medline search for SGLT2i (dapagliflozin, empagliflozin, canagliflozin, ipragliflozin, ertugliflozin, luseogliflozin) was performed, collecting all randomized trials with a duration of treatment≥12weeks, enrolling patients with type 2 diabetes, and comparing a SGLT2i with placebo or other comparators. The principal outcome was the effect of SGLT2i on ketoacidosis as serious adverse event.<bold>Results: </bold>Out of 72 trials reporting information on DKA, 9 reported at least one event of ketoacidosis; those eight trials enrolled 10,157 and 5396 in SGLT-2 inhibitors and comparator groups, respectively. No signal of increased risk for ketoacidosis was observed for SGLT2 inhibitors as a class (MH-OR [95% CI] 1.14 [0.45-2.88], p=0.78) or as individual molecule. The sensitivity analysis with continuity correction (inputing one event each in drug and comparator arms of each trial with zero events) suggested a reduced incidence of ketoacidosis in patients treated with SGLT-2 inhibitors (MH-OR 0.65 [0.47-0.90]; p=0.01).<bold>Conclusions: </bold>The results of clinical trials summarized in the present meta-analysis reassure us that, when the drug is properly prescribed, the risk of DKA is negligible. [ABSTRACT FROM AUTHOR]
- Subjects :
- *DIABETIC acidosis
*SODIUM-glucose cotransporters
*RANDOMIZED controlled trials
*ADVERSE health care events
*KIDNEY tubules
*CLINICAL trials
*COMPARATIVE studies
*HYPOGLYCEMIC agents
*RESEARCH methodology
*MEDICAL cooperation
*META-analysis
*TYPE 2 diabetes
*RESEARCH
*SYSTEMATIC reviews
*EVALUATION research
*TREATMENT effectiveness
*PHARMACODYNAMICS
Subjects
Details
- Language :
- English
- ISSN :
- 01688227
- Volume :
- 130
- Database :
- Academic Search Index
- Journal :
- Diabetes Research & Clinical Practice
- Publication Type :
- Academic Journal
- Accession number :
- 124301985
- Full Text :
- https://doi.org/10.1016/j.diabres.2017.04.017