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Thermo-sensitive random poly( L -alanine- co - L -lactic acid) with no cytotoxicity by the structure-controlled synthesis for a nano-drug carrier.
- Source :
-
International Journal of Polymer Analysis & Characterization . 2017, Vol. 22 Issue 5, p435-446. 12p. - Publication Year :
- 2017
-
Abstract
- A random poly(L-alanine-co-L-lactic acid) (PAL) with excellent thermo-sensitivity and no cytotoxicity was synthesized by the structure-controlled polycondensation from naturalL-alanine andL-lactic acid. Only those PALs in which the contents ofL-alanine structural unit are rigidly controlled in the smaller range of 53–65% show a reversible lower critical solution temperature of 35–60°C. The change of secondary structure in poly(L-alanine) segments by the introduction ofL-lactic acid structural unit plays a decisive role in regulating the thermo-sensitivity of PAL. The viability of HeLa cells exposed to PAL reaches up to 91–116% after incubation of 24 and 72 h, indicating no cytotoxicity. Furthermore, PAL can easily form curcumin-loaded nano-carriers through its thermo-sensitivity and self-assembly. The curcumin-loaded PAL nano-particles are observed to clearly internalize into the cells by confocal laser-scanning microscopy, and thus can be used as a potential nano-drug-carrier. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 1023666X
- Volume :
- 22
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- International Journal of Polymer Analysis & Characterization
- Publication Type :
- Academic Journal
- Accession number :
- 124365017
- Full Text :
- https://doi.org/10.1080/1023666X.2017.1315480