Superparamagnetic LaSrMnO3 nanoparticles for magnetic nanohyperthermia and their biocompatibility.

The nanohyperthermia investigation of superparamagnetic La 0.77 Sr 0.23 MnO 3 nanoparticles synthesized by hydrothermal method has been carried out. The synthesized nanoparticles are found to be highly uniform in size and shape with average particle size 18 nm. Structural analysis confirms the pseudo-cubic perovskite crystal structure with space group of ( R 3 c ). The magnetization versus applied magnetic field (M-H) hysteresis loops measurements revealed the superparmagnetic nature of the synthesized nanoparticles. The induction heating of synthesized nanoparticles for their applications in nanohyperthermia has been studied. The in vitro cytotoxicity test of the synthesized superparamagnetic nanoparticles has been probed by evaluating the viability of HeLa (Human Negroid Cervix Epitheloid Carcinoma) cell lines. The mechanism responsible for nanohyperthermia heating of the synthesized nanoparticles has been discussed. [ABSTRACT FROM AUTHOR]