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Long-term follow-up of bilateral subthalamic deep brain stimulation for refractory tardive dystonia.
Long-term follow-up of bilateral subthalamic deep brain stimulation for refractory tardive dystonia.
- Source :
-
Parkinsonism & Related Disorders . Aug2017, Vol. 41, p58-65. 8p. - Publication Year :
- 2017
-
Abstract
- <bold>Background: </bold>No effective treatment for tardive dystonia (TD) has been well established. Deep brain stimulation (DBS) can ameliorate motor manifestations in primary dystonia, and may also be an effective approach for TD.<bold>Objectives: </bold>This study aimed to illuminate the long-term efficacy and safety of subthalamic nucleus (STN)-DBS in treating TD.<bold>Methods: </bold>Ten patients with refractory TD underwent STN-DBS therapy and were assessed by the Burke-Fahn-Marsden dystonia rating scale (BFMDRS), Abnormal Involuntary Movement Scale (AIMS), Hamilton Depression Scale (HAMD), Hamilton Anxiety Scale (HAMA), and the Short Form (36) Health Survey (SF-36) at four time points: pre-operation, 1 week post-operation, 6 months post-operation, and at a final long-term postsurgical follow-up time point.<bold>Results: </bold>The mean follow-up time was 65.6 ± 30.4 months (range, 12-105 months). At the first follow-up, BFMDRS motor and disability scores had improved by 55.9± 28.3% and 62.6± 32.0%, respectively, while AIMS scores improved by 53.3± 26.7%. At the second follow-up, BFMDRS motor and disability scores improved further, by 87.3± 17.0% and 84.3% ± 22.9%, respectively, while AIMS scores improved by 88.4 ± 16.1%. At the last follow-up, this benefit was sustained and had plateaued. Quality of life was improved significantly at the long-term follow-up, and the HAMA and HAMD scores displayed a significant reduction that persisted after the first follow-up.<bold>Conclusion: </bold>STN-DBS may be an effective and acceptable procedure for TD, leading to persistent and significant improvement in both movement and psychiatric symptoms. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 13538020
- Volume :
- 41
- Database :
- Academic Search Index
- Journal :
- Parkinsonism & Related Disorders
- Publication Type :
- Academic Journal
- Accession number :
- 124383812
- Full Text :
- https://doi.org/10.1016/j.parkreldis.2017.05.010