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Chemical proteomics reveal CD147 as a functional target of pseudolaric acid B in human cancer cells.
- Source :
-
Chemical Communications . 8/11/2017, Vol. 53 Issue 62, p8671-8674. 4p. - Publication Year :
- 2017
-
Abstract
- CD147 is a glycosylated transmembrane protein highly expressed on the surface of various tumor cells which plays vital roles in tumor invasion, progression and metastasis. We report the discovery of the natural product pseudolaric acid B (PAB) directly targeting CD147 by chemical proteomics utilizing a PAB-derived photoaffinity probe which could serve as a novel type of anticancer reagent. [ABSTRACT FROM AUTHOR]
- Subjects :
- *PROTEOMICS
*MEMBRANE proteins
*CANCER cells
Subjects
Details
- Language :
- English
- ISSN :
- 13597345
- Volume :
- 53
- Issue :
- 62
- Database :
- Academic Search Index
- Journal :
- Chemical Communications
- Publication Type :
- Academic Journal
- Accession number :
- 124419396
- Full Text :
- https://doi.org/10.1039/c7cc04345g