Polyethylene glycol methacrylate-grafted dicationic imidazolium-based ionic liquid: Heterogeneous catalyst for the synthesis of aryl-benzo[4,5]imidazo[1,2-a]pyrimidine amines under solvent-free conditions.

A novel polyethylene glycol methacrylate-grafted tetra-ethylene glycol-bridged dicationic imidazolium-based ionic liquid (PEGMA- g -TEGBDIM) was prepared by grafting tetra-ethylene glycol-bridged 1-vinyl imidazolium mesylate to the surface of cross-linked polyethylene glycol methacrylate. Its structure was characterized by FT–IR, NMR, TGA, and XPS. Due to the combination of polymer-supports and flexible imidazolium linkers, it acted as a heterogeneous catalyst to exhibit excellent catalytic activity for the efficient synthesis of N -methyl-2-nitro-aryl-benzo[4,5]imidazo[1,2- a ]pyrimidine amines via the multicomponent reaction of 1 H -benzo[ d ]imidazol-2-amine ( 1 ) and ( E )- N -methyl-1-(methylthio)-2-nitroethenamine ( 3 ) with a variety of aldehydes under solvent-free conditions. Moreover, PEGMA- g -TEGBDIM was easily reused and it maintained its high catalytic activity and stability even after seven reaction-cycles. This protocol perfectly obeys the features of green chemistry, including having no waste regarding side-products, being solvent-free, and having free from column chromatographic purification. [ABSTRACT FROM AUTHOR]