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Increased Serum Interleukin-10 but not Interleukin-4 Level in Children with Mycoplasma pneumoniae Pneumonia.
- Source :
-
Journal of Tropical Pediatrics . Aug2017, Vol. 63 Issue 4, p294-300. 7p. - Publication Year :
- 2017
-
Abstract
- <bold>Background: </bold>Mycoplasma pneumoniae (MP) is a common cause of community-acquired pneumonia in children, and it has been associated with wheezing. The aim of this study was to examine the serum level of interleukin (IL)-4 and IL-10 in children with Mycoplasma pneumoniae pneumonia (MPP) and to analyse them in relation to the presence of wheezing.<bold>Methods: </bold>The study included 166 children with radiologically confirmed pneumonia. MP infection was confirmed by enzyme-linked immunosorbent assay (ELISA) serum MP-IgM and MP-IgG test and throat swab MP DNA with real-time polymerase chain reaction. Serum levels of IL-4 and IL-10 were measured using ELISA.<bold>Results: </bold>There was no significant difference in serum level of IL-4 between children with MPP and those with non-MPP. Among children with MPP, we found similar level of IL-4 regardless of the personal and family history of allergy and asthma or the presence of wheezing. A significantly higher level of IL-10 was found in children with MPP than in children with non-MPP (32.92±18.582 vs. 27.01±14.100 pg/ml, p =0.022). Furthermore, wheezing children with MPP had a significantly higher level of IL-10 than children with MPP without wheezing (43.75±26.644 vs. 27.50±10.211 pg/ml, p=0.027).<bold>Conclusion: </bold>Our results show significantly increased serum level of IL-10 in children with MPP, which was significantly higher in children with wheezing. These findings may suggest a role of IL-10 in the pathogenesis of MPP and in the occurrence of wheezing during acute MP infection. [ABSTRACT FROM AUTHOR]
- Subjects :
- *MYCOPLASMA pneumoniae infections
*PNEUMONIA in children
*COMMUNITY-acquired pneumonia
*INTERLEUKIN-10
*INTERLEUKIN-4
*WHEEZE
*ASTHMA
*DNA
*ENZYME-linked immunosorbent assay
*INTERLEUKINS
*LONGITUDINAL method
*MYCOPLASMA
*POLYMERASE chain reaction
*RESPIRATORY organ sounds
*COMMUNITY-acquired infections
*CROSS-sectional method
*BACTERIAL antibodies
*DISEASE complications
*DIAGNOSIS
Subjects
Details
- Language :
- English
- ISSN :
- 01426338
- Volume :
- 63
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Journal of Tropical Pediatrics
- Publication Type :
- Academic Journal
- Accession number :
- 124422865
- Full Text :
- https://doi.org/10.1093/tropej/fmw091