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Phenolic polyketides from the marine alga-derived Streptomyces sp. OUCMDZ-3434.
- Source :
-
Tetrahedron . Sep2017, Vol. 73 Issue 36, p5451-5455. 5p. - Publication Year :
- 2017
-
Abstract
- Five new phenolic polyketides, namely 3- O -methylwailupemycin G ( 1 ), wailupemycin J ( 2 ), R - and S -wailupemycin K ( 3 and 4 ) and wailupemycin L ( 5 ), as well as the known enterocin ( 6 ) and 5-deoxyenterocin ( 7 ) were isolated and identified from the fermentation broth of Streptomyces sp. OUCMDZ-3434 associated with the marine green algae, Enteromorpha prolifera . Their structures including absolute configurations were elucidated according to the spectroscopic analysis, X-ray single crystal diffraction and the Mosher's experiments. Compound 1 showed comparable α -glucosidase inhibition with an IC 50 value of 0.86 mM to acarbose (IC 50 1.12 mM), and compound 4 was cytotoxic on the HeLa cell with an IC 50 value of 8.2 μM. Compounds 2 , 3 and 7 showed anti-H1N1 virus activity with 47.8%, 42.5% and 60.6% inhibitions, respectively at 50 μg/mL (ribavirin, 45.3% inhibition). [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00404020
- Volume :
- 73
- Issue :
- 36
- Database :
- Academic Search Index
- Journal :
- Tetrahedron
- Publication Type :
- Academic Journal
- Accession number :
- 124526282
- Full Text :
- https://doi.org/10.1016/j.tet.2017.07.052