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Closing the gap: long-term presynaptic plasticity in brain function and disease.
- Source :
-
Current Opinion in Neurobiology . Aug2017, Vol. 45, p106-112. 7p. - Publication Year :
- 2017
-
Abstract
- Synaptic plasticity is critical for experience-dependent adjustments of brain function. While most research has focused on the mechanisms that underlie postsynaptic forms of plasticity, comparatively little is known about how neurotransmitter release is altered in a long-term manner. Emerging research suggests that many of the features of canonical ‘postsynaptic’ plasticity, such as associativity, structural changes and bidirectionality, also characterize long-term presynaptic plasticity. Recent studies demonstrate that presynaptic plasticity is a potent regulator of circuit output and function. Moreover, aberrant presynaptic plasticity is a convergent factor of synaptopathies like schizophrenia, addiction, and Autism Spectrum Disorders, and may be a potential target for treatment. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09594388
- Volume :
- 45
- Database :
- Academic Search Index
- Journal :
- Current Opinion in Neurobiology
- Publication Type :
- Academic Journal
- Accession number :
- 124578494
- Full Text :
- https://doi.org/10.1016/j.conb.2017.05.011