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T Cell Zone Resident Macrophages Silently Dispose of Apoptotic Cells in the Lymph Node.
- Source :
-
Immunity (10747613) . Aug2017, Vol. 47 Issue 2, p349-362.e5. 1p. - Publication Year :
- 2017
-
Abstract
- Summary In lymph nodes (LNs), dendritic cells (DCs) are thought to dispose of apoptotic cells, a function pertaining to macrophages in other tissues. We found that a population of CX3CR1 + MERTK + cells located in the T cell zone of LNs, previously identified as DCs, are efferocytic macrophages. Lineage-tracing experiments and shield chimeras indicated that these T zone macrophages (TZM) are long-lived macrophages seeded in utero and slowly replaced by blood monocytes after birth. Imaging the LNs of mice in which TZM and DCs express different fluorescent proteins revealed that TZM—and not DCs—act as the only professional scavengers, clearing apoptotic cells in the LN T cell zone in a CX3CR1-dependent manner. Furthermore, similar to other macrophages, TZM appear inefficient in priming CD4 T cells. Thus, efferocytosis and T cell activation in the LN are uncoupled processes designated to macrophages and DCs, respectively, with implications to the maintenance of immune homeostasis. [ABSTRACT FROM AUTHOR]
- Subjects :
- *T cells
*MACROPHAGES
*LYMPH nodes
*APOPTOSIS
*MONOCYTES
*LABORATORY mice
*HOMEOSTASIS
Subjects
Details
- Language :
- English
- ISSN :
- 10747613
- Volume :
- 47
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Immunity (10747613)
- Publication Type :
- Academic Journal
- Accession number :
- 124606318
- Full Text :
- https://doi.org/10.1016/j.immuni.2017.07.019