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Asymmetric Michael Addition Organocatalyzed by α,β-Dipeptides under Solvent-Free Reaction Conditions.
- Source :
-
Molecules . Aug2017, Vol. 22 Issue 8, p1328. 44p. 19 Diagrams, 9 Charts, 22 Graphs. - Publication Year :
- 2017
-
Abstract
- The application of six novel α,β-dipeptides as chiral organocatalysts in the asymmetric Michael addition reaction between enolizable aldehydes and N-arylmaleimides or nitroolefins is described. With N-arylmaleimides as substrates, the best results were achieved with dipeptide 2 as a catalyst in the presence of aq. NaOH. Whereas dipeptides 4 and 6 in conjunction with 4-dimethylaminopyridine (DMAP) and thiourea as a hydrogen bond donor proved to be highly efficient organocatalytic systems in the enantioselective reaction between isobutyraldehyde and various nitroolefins. [ABSTRACT FROM AUTHOR]
- Subjects :
- *DIPEPTIDES
*ASYMMETRIC synthesis
*ALDEHYDES
*DIMETHYLANILINE
*HYDROGEN bonding
Subjects
Details
- Language :
- English
- ISSN :
- 14203049
- Volume :
- 22
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- Molecules
- Publication Type :
- Academic Journal
- Accession number :
- 124869592
- Full Text :
- https://doi.org/10.3390/molecules22081328